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3 questions on pharmacokinetics

1)If equal volumes of intestinal juice (pH = 5.4) and plasma (pH = 7.4) were separated by an
epithelial membrane, what would be the ratio of concentrations (plasma/intestinal juice) achieved
by an organic acid (pKa = 6.4)? An organic base (pKa = 6.4)?

2)If a drug has an elimination rate constant (Ke) of 0.3 days-1, how much time is required for
elimination of 95% of the drug?

3)A drug has a half-life of 3.5 hours, and a fractional Vd of 0.6 L/kg. If the drug is administered
by IV infusion to a 65 kg man at a constant rate of 2 mg/min, what will be the steady-state
plasma concentration? How long will it take to reach 95% of that concentration

please dont send me the answers only hints in each question
thanx

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