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    Hello,

    Is it possible to use sperm to diagnose the presence of a recessive genetic disease using the RFLP technique?
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    If you are already aware of RFLPs that co-segregate with the disease then yes RFLP analysis would be a useful diagnostic tool - otherwise probably not because a polymorphism in and of itself doesn't mean that an allele is recessive or disease-associated necessary
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    Can we use Sperm for that?
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    You can use any source of DNA so yes - however since sperm are haploid they won't tell you whether the individual producing them is heterozygous or homozygous for the recessive trait (without sampling more than one, in which case you might as well use a somatic cell for convenience), so I can't see much point to using one.
 
 
 
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