Question on protein synthesis and dna

Oligonucleotides are short chains of nucleotides. Some of these are man-made and have been used to treat a wide variety of diseases. They work by binding to mRNA or DNA and inhibiting protein synthesis. The drugs are described as antisense drugs when they bind to mRNA and triplex drugs when they bind to DNA.

Which stage of the protein synthesis will be inhibited by each of the following:

Antisense drug ........................

Triplex Drug ........................

Base sequence in mRNA --- AGUCAU
Base sequence in antisense drug ---- ??? Is it UCAGUA?

Reply 1

nevetstreblig

Antisense drug: Antisense drugs provide another length of nucleotides to bond to mRNA which 'cancels' it out...so protein syn. cannot occur using that strand.
Triplex drug:...no idea :P
Base sequence...looks like it!

Reply 2

Jale

Triplex drugs typically prevent transcription itself, though I am not sure it is fully understood. Probably down to stopping factors binding, or stopping the procession of the transcription machinery.

Reply 3

happykidhan7700

Antisense drug - translation
Triplex drug - transcription

(edited 2 years ago)

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