Yep.
The scenario you raised that bothers me least of all is the infertility. A few years ago, doctors suspected that I might be infertile (long story - Turns out i'm not, woo) so had to go through a bit of time with that idea over my head. I know this situation will probably be the one that would be most offputting to another person (and obviously so, having your own child is a big deal) but to me, it's not that much of a big deal. It's a massive shame, of course it is, but at the end of the day there are over things that can be done (i.e adoption) so that you can have a family.
Not to make jokes, either, but the chances are if my girlfriend lost her limbs, she'd weigh less than other people i'd meet!