Bobby132
Badges: 0
Rep:
?
#1
Report Thread starter 8 years ago
#1
My understanding is that oestrogen causes cells in the uterus lining to divide, causing it to thicken. Then progesterone causes the cells to stop dividing and capillaries and glands (which secrete glucose, mucus) to grow into the cell lining.

I have found many sources which say both things, which is frustrating, I don't see how it can be both.

Also I also can't find anything on the role of uterus contractions are on menstruation.
During the period strong contractions cut off blood to the lining, which causes it do die during menstruation, but do the physical contractions themselves cause the lining to fall off, or does it just fall off on its own? And what is the point of the uterus contractions which happen throughout the throughout the entire cycle and not just during the period?

Sources on progesterone and its effect on the uterus lining:
http://www.einstein.yu.edu/centers/r...iferation.aspx

In the epithelial cells estradiol-17ß (E2) stimulates cell division whereas progesterone (P4) inhibits this E2induced cell proliferation while at the same time preparing the epithelium for the reception of the blastocyst prior to implantation

http://www.ivfconnections.com/forums...wth-Discovered

the scientists identified a protein, called Hand2, that assists in the preparation of the uterine lining for implantation. This protein is triggered by progesterone, stopping the growth of the uterine lining at the optimal thickness for embryo implantation.

in mice:
http://www.ncbi.nlm.nih.gov/pubmed/10022912

"(E2) stimulates a synchronized wave of DNA synthesis and cell division in the epithelial cells, while pretreatment with progesterone (P4) completely inhibits this E2-induced cell proliferation."

http://www.asrm.org/Noncontraceptive...lls_factsheet/

Women who have menstrual cycles longer than 35 days might not be making progesterone, which prevents the uterine lining from growing too much.

http://www.glowm.com/index.html?p=gl...&articleid=293

Progestins not only stop endometrial growth, but also provide support and organize the endometrium so that sloughing occurs in an organized fashion.

"progesterone completes the development of the uterus lining, which thickens" - EDEXCEL IGCSES Biology

http://www.premierfertility.com/infe...dications.aspx

"Progesterone causes the endometrial lining to thicken and become more vascular to support a developing embryo"

http://leavingbio.net/human%20reproduction-web.htm

"The progesterone causes the endometrium to continue to thicken"

http://www.sharedjourney.com/define/progeterone.html

"Progesterone helps to thicken the endometrial lining"
0
reply
aprilreverie
Badges: 0
Rep:
?
#2
Report 6 years ago
#2
Progesterone maintains the lining. The contractions are caused as a result of the lining falling off (which is due to falling oestrogen + progesterone levels.) The uterus only contracts during the period.
0
reply
X

Quick Reply

Attached files
Write a reply...
Reply
new posts
Back
to top
Latest
My Feed

See more of what you like on
The Student Room

You can personalise what you see on TSR. Tell us a little about yourself to get started.

Personalise

If you haven't confirmed your firm and insurance choices yet, why is that?

I don't want to decide until I've received all my offers (2)
50%
I am waiting until the deadline in case anything in my life changes (1)
25%
I am waiting until the deadline in case something in the world changes (ie. pandemic-related) (1)
25%
I am waiting until I can see the unis in person (0)
0%
I still have more questions before I made my decision (0)
0%
No reason, just haven't entered it yet (0)
0%
Something else (let us know in the thread!) (0)
0%

Watched Threads

View All