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    Hey Guys, I'm a little confused..

    I understand the processes of each one, i know that both are set off by a damaged blood vessel and in atherosclerosis white blood cells accumulate fatty substances whereas in blood clotting platelet plug make a platelet plug and release thromboplastin etc..

    But i dont understand what determines which of these processes will occur. Surely there are white blood cells and platelets in the blood at all times, so why don't white blood cells create an atheroma in veins when damaged as opposed to a thrombosis forming? Or do they? Is it just dependent on whether the white blood cells or the platelets react with the damaged wall first?
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    (Original post by brainybonsai)
    Hey Guys, I'm a little confused..

    I understand the processes of each one, i know that both are set off by a damaged blood vessel and in atherosclerosis white blood cells accumulate fatty substances whereas in blood clotting platelet plug make a platelet plug and release thromboplastin etc..

    But i dont understand what determines which of these processes will occur. Surely there are white blood cells and platelets in the blood at all times, so why don't white blood cells create an atheroma in veins when damaged as opposed to a thrombosis forming? Or do they? Is it just dependent on whether the white blood cells or the platelets react with the damaged wall first?
    I think it's to do with whether or not lipoproteins enter the blood vessel wall? If they do so, then this could potentially lead to atherosclerosis. (The lipoproteins contain the "fatty substance" which is then taken up by the white blood cells in the vessel wall.)

    And atherosclerosis damages the wall, so can lead to thrombus.

    I imagine damage to the wall could lead to both clotting and the beginning of athersclerosis occurring.
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    Blood travels at higher pressure in the arteries which means there is higher risk of peripheral resistance and damage to the endothelium of the artery. This damage can create the development of the whole process of atherosclerosis and eventually the formation of an atheroma.


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