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    Yeah. Pretty much what the title says. I was delving a little deeper into atherosclerosis for my AS Biology exam, and a video on YouTube said that the oxidation of cholesterol causes it to become toxic and triggers the inflammatory response.

    Can't find anything on the internet about it, and I'm certain I don't need it for my exam. But can anyone help me out?
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    (Original post by StephenNaulls)
    Yeah. Pretty much what the title says. I was delving a little deeper into atherosclerosis for my AS Biology exam, and a video on YouTube said that the oxidation of cholesterol causes it to become toxic and triggers the inflammatory response.

    Can't find anything on the internet about it, and I'm certain I don't need it for my exam. But can anyone help me out?
    There are two types of lipoprotein - low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL belongs to the "bad cholesterol" group and transports lipids around the body. When there is an excess of lipids in the diet they accumulate in the sub-endothelial layer of arteries (just below the surface). This happens naturally in everyone. In a high-fat diet this process is exaggerated and the lipids are oxidised to LDL by enzymes. This 'activates' the endothelial wall of the artery and expresses molecules to attract immune cells in the blood causing cells such as macrophages to reside in the vessel wall. The macrophages increase and elongate the inflammatory response. These are a main factor in the inflammatory response here.

    I hope that was slightly okay to understand?
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    Yeah, that's great. Thanks! I'll rep you tomorrow, I've ran out today -.-
 
 
 
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