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whoever answers this is a GENIUS:"why does BRD inh. have antipoliferative effects" * Watch

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    i know we can stop brd 4 from reaching the acetyl region but surely that means there is no transcription of mRNA?
    isnt that a bad thing like for cancer ?
    how does it have antipoliferative effects?
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    Acetyl region of what? Your question is not very clear. You need to give some context!
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    (Original post by alleycat393)
    Acetyl region of what? Your question is not very clear. You need to give some context!
    histones?
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    Right so acetyl marks on histones are activiating marks. Brd4 is a bromodomain containing protein. Bromodomains recognise these acetyl marks and target genes on located on these histones for transcription. Blocking Brd4 means that genes required for the cell cycle for example cannot be targeted for transcription, the cell cannot replicate. Hence blocking Brd4 has anti-proliferative effects. A simplified concept of cancer is that it is caused by uncontrolled cell division.
 
 
 
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