Can someone please explain how b lymphocytes and t lymphocytes work together when activated by the immune system? I just can't get my head around it for some reason and it seems pretty easy!
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- Thread Starter
- 18-03-2013 20:30
- 18-03-2013 21:04
B-lymphocytes - Antibody-mediated response (free foreign antigens)
T-lymphocytes - Cell-mediated response (foreign antigens on virus infected cells, transplant tissue and tumors)
In short when sensitised, T-cells differentiate into many cells, one of which is a Helper T-cell. This helps stimulate (via interferon) B-cells to differentiate into plasma cells for the production of antibodies to agglutinate free foreign antigens.Last edited by LeJoshing; 18-03-2013 at 21:17.
- 18-03-2013 21:09
It is actually quite a complicated process (the interactions between B and T cells at the point of infection) and during sixth form it is a topic that did confuse me slightly as the teaching material felt like, and was, full of holes..
Basically B cells are responsible for antibody secretion and are more often than not T cell dependent. This means that they require cytokines, that the T cell secretes upon recognising a specific antigen, to trigger differentiation into their 'active' form, a plasma B cell.