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    • Thread Starter

    Can someone please explain how b lymphocytes and t lymphocytes work together when activated by the immune system? I just can't get my head around it for some reason and it seems pretty easy!

    Reply ASAP thanks

    B-lymphocytes - Antibody-mediated response (free foreign antigens)
    T-lymphocytes - Cell-mediated response (foreign antigens on virus infected cells, transplant tissue and tumors)

    In short when sensitised, T-cells differentiate into many cells, one of which is a Helper T-cell. This helps stimulate (via interferon) B-cells to differentiate into plasma cells for the production of antibodies to agglutinate free foreign antigens.

    It is actually quite a complicated process (the interactions between B and T cells at the point of infection) and during sixth form it is a topic that did confuse me slightly as the teaching material felt like, and was, full of holes..

    Basically B cells are responsible for antibody secretion and are more often than not T cell dependent. This means that they require cytokines, that the T cell secretes upon recognising a specific antigen, to trigger differentiation into their 'active' form, a plasma B cell.
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