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    • Thread Starter

    Hey guys so I'm a bit confused so basically I understand how billrubin is broken down and how it is conjugated which makes it water soluble and allows it to be excreted in bile or reabsorbed. However I understand that in neonates there is an enzyme which is able to convert the conjugated billrubin to an unconjugated form and then this unconjugated form can enter the enterohepatic circulation. However I'm not sure how the unconjugated billirubin is able to enter the enterohepatic circulation as it is fat soluble and NOT water soluble.

    Any clarification would be appreciated

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