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    I have written in my notes something about a "chloride shift". It's messy and not very well done. All I know is that it has something to do with pH and blood.

    Can someone please explain chloride shift to me? :3

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    (Original post by JonnyD)
    I have written in my notes something about a "chloride shift". It's messy and not very well done. All I know is that it has something to do with pH and blood.

    Can someone please explain chloride shift to me? :3

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    Memory may be a bit rusty.

    But basically CO2 enters a red blood cell.
    Combines with H2O and we get carbonic acid H2CO3.
    Carbonic acid dissociates into hydrogencarbonate, HCO3- and hydrogen H+ ions.
    Hydrogencarbonate ions then diffuse out of the red blood cells into the blood plasma.
    Chloride ions therefore go into the red blood cells to maintain charge (otherwise blood cells would be positively charged...).
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    Thank you

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