T-cell costimulatory molecules Watch

jsmith6131
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for T-cells to become activated they need costimulatory molecules. How and where are these co-stimulatory molecules produced?
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Hype en Ecosse
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(Original post by jsmith6131)
for T-cells to become activated they need costimulatory molecules. How and where are these co-stimulatory molecules produced?
I can't give you an exact molecular pathway, but co-stimulatory molecules tend to be created by APCs and presented on the surface of the antigen-presenting cells. Accompanying receptors are produced within the T-cell and expressed on the surface near the TCR. Probably the most well-studied costimulatory system is the CD28:B7 interaction - so you might want to read about that as it'd be good to know an example.
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