Nose bleeds - you can have the vein 'closed' as such - it's a very small surgery, begins with a c, but I can't spell it.
Tiredness - may be the smoking, but a lot can be affected by diet or lifestyle, look into that first, even if you do get sleep!
The eyes - might be something to do with the tiredness.
Toilet - that's not too irregular, but to be honest, all of this should be at the attention of proper medical advice.
To the doctors with ye!