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    Hi All,



    I am trying to figure out the structural differences between methotrexate (bottom) and folic acid (top). I can physically see the differences i.e. to the left of the molecule but I'm unsure how to describe it for example if that makes sense. Would appreciate any help!
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    (Original post by Joaqueem)
    Hi All,

    [IMG][/IMG]

    I am trying to figure out the structural differences between methotrexate (bottom) and folic acid (top). I can physically see the differences i.e. to the left of the molecule but I'm unsure how to describe it for example if that makes sense. Would appreciate any help!
    The amine in methotrexate is replaced by a ketone in folic acid. The double bond of the ketone means that the ring system can no longer be aromatic. The secondary amine is also methylated to a tertiary amine.
 
 
 
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