username459260
Badges: 16
Rep:
?
#1
Report Thread starter 7 years ago
#1
In their "Physiology" book, Berne/Levy's write: "Angiotensin II is produced systemically and locally within the kidneys. It constricts the afferent and efferent arterioles and decreases RBF and GFR."
Why does it reduce GFR? If it constricts efferent more than afferent surely hydrostatic pressure should INCREASE therefore GFR should increase too?
Thanks
0
reply
Hype en Ecosse
  • Study Helper
Badges: 20
Rep:
?
#2
Report 7 years ago
#2
(Original post by jsmith6131)
In their "Physiology" book, Berne/Levy's write: "Angiotensin II is produced systemically and locally within the kidneys. It constricts the afferent and efferent arterioles and decreases RBF and GFR."
Why does it reduce GFR? If it constricts efferent more than afferent surely hydrostatic pressure should INCREASE therefore GFR should increase too?
Thanks
Any decrease in renal blood flow leads to a decrease in GFR. Constriction of the afferent arteriole always leads to a decrease in RBF, even if it is accompanied by constriction of the efferent arteriole (if you don't have much coming in, then you're not going to build a very high glomerular pressure to drive GFR!)

Posted from TSR Mobile
0
reply
Revenged
Badges: 15
Rep:
?
#3
Report 7 years ago
#3
Wikipaedia says angiotensin 2 vasoconstricts the efferent causing increased pressure and increase gfr (goggle ace inhibitors, adverse effects).

ace inhibitors reduce angiotensin 2 and the side effect of renal impairment, ie reduced gfr, is a common.
0
reply
username459260
Badges: 16
Rep:
?
#4
Report Thread starter 7 years ago
#4
(Original post by Hype en Ecosse)
Any decrease in renal blood flow leads to a decrease in GFR. Constriction of the afferent arteriole always leads to a decrease in RBF, even if it is accompanied by constriction of the efferent arteriole (if you don't have much coming in, then you're not going to build a very high glomerular pressure to drive GFR!)

Posted from TSR Mobile
thanks
0
reply
X

Quick Reply

Attached files
Write a reply...
Reply
new posts
Back
to top
Latest
My Feed

See more of what you like on
The Student Room

You can personalise what you see on TSR. Tell us a little about yourself to get started.

Personalise

Should the school day be extended to help students catch up?

Yes (73)
29.8%
No (172)
70.2%

Watched Threads

View All