smileitsfree
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#1
Report Thread starter 7 years ago
#1
from my understanding diabetes results in hyperglycemia, whether its due to autoimmune destruction of b cells of the pancreas or non responsive cell receptors (to insulin)


I dont, however,understand how the cell can produce ATP if glucose isnt entering cells to undergo glycolysis. i read its something to do wish fat/protein stores but I really dont understand how?


thank you
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Random1357
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#2
Report 7 years ago
#2
I haven't done A level biology/eq (yet), but as a diabetic I know this much:

You are correct, the cells cannot use glucose in the blood stream without insulin.

If the body is unable to use glucose then it breaks down energy stores, however, this process produces ketones (toxic) so potentially causing the condition known as ketoacidosis, symptoms including entering a coma and even death.

Hope this is of some help :/
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themedicalgeek
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#3
Report 7 years ago
#3
Insulin up-regulates the amount of glucose receptors (GLUT-X) which are expressed on the cell membrane, there is always a basal number so glucose is always taken up but just not that much.
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nexttime
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#4
Report 7 years ago
#4
(Original post by smileitsfree)
I dont, however,understand how the cell can produce ATP if glucose isnt entering cells to undergo glycolysis.
Well yes you're right. Without any insulin you die quickly because of this!
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bertstare
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#5
Report 7 years ago
#5
Often there is a shift to fat metabolism and production of ketones in uncontrolled diabetes - which is what can result in ketoacidosis
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Dynamo123
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#6
Report 7 years ago
#6
(Original post by smileitsfree)

I dont, however,understand how the cell can produce ATP if glucose isnt entering cells to undergo glycolysis. i read its something to do wish fat/protein stores but I really dont understand how?


thank you
There are alternate protein and fat stores in your body. One example of the protein store would be the plasma proteins in your blood. These can be taken up by special cells,a nd broken down to liberate free amino acids and energy. Fats can also be metabolized to produce ATP and energy.

If you are at AS level, you don't really need to know how. However, if you need to understand it in detail, it would be just as well to try to understand teh basic principles of protein and lipid metabolism. Here are some animations to get you started:
http://www.wiley.com/college/grosven...a/frameset.htm
http://www.wiley.com/college/grosven...a/frameset.htm

I hope that helps.
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