Insulin and Glut4 Watch
- Study Helper
Low levels of insulin is a sign of low blood-glucose levels, thus liver cells break down glycogen into glucose and secrete into the blood to increase blood-sugar levels. For GLUT4, my guess is that the cells recycle them as they are no longer needed in low insulin levels, in order to prevent constant uptake of glucose. I couldn't find any papers on GLUT4 downregulation, so I can't be sure whether they re-enter intracellular vesicles or are simply targeted for degredation via the E3 ubiquitin ligase pathway.