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Why does prolonged depolarisation cause sodium inactivation?
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However, if there is prolonged depolarisation the membrane potential will constantly be above the threshold for voltage-gated sodium channels which stimulates them to open. Remember they can only remain open for 1-2 milliseconds before inactivating, so they will be constantly inactivated.
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(Original post by Asklepios)
Remember that voltage-gated sodium channels exist in three states - open, closed (but activated), and inactivated. In the normal action potential, a depolarising stimulus opens sodium channels, which then inactivate after 1-2 milliseconds. This combined with potassium channels opening repolarises the cell.
However, if there is prolonged depolarisation the membrane potential will constantly be above the threshold for voltage-gated sodium channels which stimulates them to open. Remember they can only remain open for 1-2 milliseconds before inactivating, so they will be constantly inactivated.
Posted from TSR Mobile
Remember that voltage-gated sodium channels exist in three states - open, closed (but activated), and inactivated. In the normal action potential, a depolarising stimulus opens sodium channels, which then inactivate after 1-2 milliseconds. This combined with potassium channels opening repolarises the cell.
However, if there is prolonged depolarisation the membrane potential will constantly be above the threshold for voltage-gated sodium channels which stimulates them to open. Remember they can only remain open for 1-2 milliseconds before inactivating, so they will be constantly inactivated.
Posted from TSR Mobile
I see thant makes perfect sense. Thank you.
Another question, there are electrical and chemical synapses. When do we get these such as, should there be speicific stimuli for an electrical synapse to be involved. Like how can we determine if something will undergo electrical or chemical synapse?If you see what I mean.
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(Original post by otrivine)
I see thant makes perfect sense. Thank you.
Another question, there are electrical and chemical synapses. When do we get these such as, should there be speicific stimuli for an electrical synapse to be involved. Like how can we determine if something will undergo electrical or chemical synapse?If you see what I mean.
I see thant makes perfect sense. Thank you.
Another question, there are electrical and chemical synapses. When do we get these such as, should there be speicific stimuli for an electrical synapse to be involved. Like how can we determine if something will undergo electrical or chemical synapse?If you see what I mean.
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