Does anyone know why the cholera toxin only affects the epithelial cells? Watch

Maya331
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It's a 3 mark question and so far I've only got one point: the bacterium produces a toxin which acts on the epithelial cells of the small intestine and causes changes in membrane permeability.

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heavyhandscott
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The epithelial cells have special carbohydrate receptors on the cell surface membrane. This allows the bacteria to specifically target these cells. Therefore, the bacteria secretes toxins which are specific to the shape of these receptors on the membrane. by binding to the receptors, it allows the toxic part of the toxin to enter the cell and change the cell permeability since it opens ion channels (which are proteins on the cell surface membrane) and causes ions to be lost since they diffuse out the high concentration of the cell to low concentration in the lumen of the intestine.

Its all to do with the carbohydrate receptor being found specifically on the epithelial cells. Hope this helped

btw this was my first post.. lucky!
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Maya331
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(Original post by heavyhandscott)
The epithelial cells have special carbohydrate receptors on the cell surface membrane. This allows the bacteria to specifically target these cells. Therefore, the bacteria secretes toxins which are specific to the shape of these receptors on the membrane. by binding to the receptors, it allows the toxic part of the toxin to enter the cell and change the cell permeability since it opens ion channels (which are proteins on the cell surface membrane) and causes ions to be lost since they diffuse out the high concentration of the cell to low concentration in the lumen of the intestine.

Its all to do with the carbohydrate receptor being found specifically on the epithelial cells. Hope this helped

btw this was my first post.. lucky!
ooh are you new? :ta: and have a rep and a banana! :banana:
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heavyhandscott
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Yah im new, loving this place too! Any other biology problems ill help. Im doing a2 biology and want to do it at Uni to be a teacher


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Maya331
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(Original post by heavyhandscott)
Yah im new, loving this place too! Any other biology problems ill help. Im doing a2 biology and want to do it at Uni to be a teacher


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Yeah ok will do, can I just ask what grade did you get in AS (I'm guessing you did well if you want to be a biology teacher) and how did you revise? I'm thinking of doing neuroscience at Manchester so I need to do really well but I'm finding it quite difficult did you just do loads of past papers?
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heavyhandscott
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I got a C and was very lucky in doing so. Yes... Papers papers papers!! Thats what got me As in double science and maths at GCSE


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