MyVow
Badges: 0
Rep:
?
#1
Report Thread starter 6 years ago
#1
For a low extraction drug, why organ clearance is poorly influenced by blood flow and protein binding? Does not the extraction rate is determined by blood flow ? (organ clearance = blood x extraction ratio)

thanks
0
reply
jumjum
Badges: 14
Rep:
?
#2
Report 6 years ago
#2
here is a list i found on a website as to why this is



2) Variation of plasma protein binding:
a) for drugs with low extraction ratio: only unbound drug penetrates membranes and is available for elimination. An increase of the unbound fraction will thus proportionally increase the clearance. Therefore, the unbound drug concentration remains constant and no adaptation of the dosage regimen is required.
b) for drugs with high extraction ratio: the organ is capable of removing all the drug presented to it, independently of plasma binding. Therefore, even if the fraction of unbound drug increases, the clearance remains constant and the unbound concentration then increases and may lead to toxicity.
3) Variation of the organ's intrinsic ability to eliminate the drug:


http://sepia.unil.ch/pharmacology/index.php?id=63



(Original post by MyVow)
For a low extraction drug, why organ clearance is poorly influenced by blood flow and protein binding? Does not the extraction rate is determined by blood flow ? (organ clearance = blood x extraction ratio)

thanks
0
reply
X

Quick Reply

Attached files
Write a reply...
Reply
new posts
Back
to top
Latest
My Feed

See more of what you like on
The Student Room

You can personalise what you see on TSR. Tell us a little about yourself to get started.

Personalise

Should there be a new university admissions system that ditches predicted grades?

No, I think predicted grades should still be used to make offers (554)
33.95%
Yes, I like the idea of applying to uni after I received my grades (PQA) (674)
41.3%
Yes, I like the idea of receiving offers only after I receive my grades (PQO) (330)
20.22%
I think there is a better option than the ones suggested (let us know in the thread!) (74)
4.53%

Watched Threads

View All