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Are there any antidepressants that don't cause nausea/sickness

I know this is a bit of a difficult question to answer as with all medication it will vary from person to person, but overall is there a particular group of antidepressants that are known to have less awful side effects? Particular feeling very sick for a while?

I have severe anxiety at the moment and I've been prescribed Prozac in the past, however I was too afraid to take it due to hearing so many horror stories of how it made users feel very sick. Same goes for Citalopram.

I know it probably sounds stupid and it's likely in many people's opinions that suffering a few weeks of side effects is preferable due to the help of the medication in the long term. However without going into major details, part of my anxiety is related to emetophobia, therefore taking something that runs the risk of causing feelings of sickness isn't really viable for me.

Again I understand this is difficult to answer as most of the drugs list nausea as a side effect but I was just interested to hear people's opinions/advice.

Thanks very much in advance. :smile:
Hey, I have emetophobia too so I understand the worry that comes with taking new meds! Just to say I've never had any problems with fluoxetine or Citalopram, nor any anti depressant I've been on (the only med that has made me feel sick as a side effect is the anti psychotic aripiprazole). But I remember hearing that the antidepressant mirtazapine can also be used as an anti-emetic so I guess the risk of that making you feel sick is pretty low. It may be hard getting a Dr to prescribe that as a first drug as normally it's prescribed if others haven't worked.

Hope that helped :smile:

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Reply 2
Original post by Anonymous
Again I understand this is difficult to answer as most of the drugs list nausea as a side effect but I was just interested to hear people's opinions/advice.
Go back to your GP and explain.

Refusing to take prescribed antidepressants is unwise.

Listed side effects are possible side effects, not likely side effects.

The GP could prescribe you anti-nausea medication too.

Don't rely on random strangers on the internet for medical advice. Go back to your GP.
How long did you take them for?

The side effects often go after 2 weeks.
(edited 9 years ago)
I'm taking prozac for depression now, I felt a teeny bit sick for about the first week and maybe a little bit more twitchy but then that all went away. That is my personal experience and as you said, it'll be different for everyone :smile:
Reply 5
Im on trazadone and there is barely any side affects :smile: I have a really sensitive stomach so citalopram made me really ill! but trazadone just makes you tired but thats really all! also mirtazapine is good too!
Hope this helps
Reply 6
Original post by Punk_Rock_Socks
I'm taking prozac for depression now, I felt a teeny bit sick for about the first week and maybe a little bit more twitchy but then that all went away. That is my personal experience and as you said, it'll be different for everyone :smile:
When you say twitchy what do you mean like ful muscles twitch or the small twitches in various parts of your body?
Original post by Ebony19
When you say twitchy what do you mean like ful muscles twitch or the small twitches in various parts of your body?


It's just like small twitches, its not bad enough to disturb whatever I'm doing. Sorry i cant explain it any better!
Reply 8
Original post by Punk_Rock_Socks
It's just like small twitches, its not bad enough to disturb whatever I'm doing. Sorry i cant explain it any better!
That makes sense like not a whole muscle just a small part of you twitches
I see mirtazapine has already been mentioned. I second that. However whenever I went cold turkey on it I felt incredibly nauseated (although didn't actually throw up). Just something to be aware of. :smile:

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Reply 10
Im on 40mg Citalopram atm and I find thats pretty ok, mainly symptom-less once youre into it.

I wouldnt recommend Fluroxetine - that gave me such unimaginably bad stomach ache - but I guess everyone is different.

Shop about a bit, theres plenty about that have the pros and cons.

So yeah, Citalopram is good - just dont expect to have any/fun sex whilst youre getting used to it XD
I was on Fluoxetine first and I was severely ill, lost a lot of weight e.t.c so I took myself off them. I'm now on Citalopram and had the dosage upped recently, the doctor however prescribed anti sickness tablets to go with them. I find I don't need to take them anymore and the Citalopram is much better :smile:
I took Fluoxetine and never had any problems on it. Certainly no sickness or nausea.

I came off it easily as well. Just stopped taking it and no problems at all.
Reply 13
My doctor prescribed Citalopram for hot flushes. Worked well but the only side effect I had was urinary stress incontinence which I wasn't prepared to live with. I am now, a few years later, suffering depression and am seeing my GP today but am terrified of being given an antidepressant that makes my hair thin (list it all when I had cancer so quite keen to keep it all now), makes me nauseous or piles on the weight. Currently taking Gabapentin for hot flushes and peripheral neuropathy (which was actually caused by statinsPrescribed, so they're in the bin now) but want to stop taking it. Any help gratefully received.
Citalopram make me really ill my partner had to phone the ambulance as I was hallucinating, being sick, shaking and in agony with chest pains. Turns out it was an allergic reaction to citalopram. Really frightened to try any others now :frown:
I was on celexa, 20 mg. Became very sick. Was then prescribed fluoxetine. Same thing happened. Both also gave me excessive diarrhea and I was constantly crying uncontrollably. Now we are back to trying to find something that works. Side note, I also took anti nausea meds but they still didn't help.
Original post by Anonymous
I know this is a bit of a difficult question to answer as with all medication it will vary from person to person, but overall is there a particular group of antidepressants that are known to have less awful side effects? Particular feeling very sick for a while?

I have severe anxiety at the moment and I've been prescribed Prozac in the past, however I was too afraid to take it due to hearing so many horror stories of how it made users feel very sick. Same goes for Citalopram.

I know it probably sounds stupid and it's likely in many people's opinions that suffering a few weeks of side effects is preferable due to the help of the medication in the long term. However without going into major details, part of my anxiety is related to emetophobia, therefore taking something that runs the risk of causing feelings of sickness isn't really viable for me.

Again I understand this is difficult to answer as most of the drugs list nausea as a side effect but I was just interested to hear people's opinions/advice.

Thanks very much in advance. :smile:


I’m having this exact same problem right now did you ever get any answers ? I’m super scared to try meds but I can’t live with this much anxiety