why does glucose need to be phosphorylated in gylcolysis

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Commando1
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#1
Report Thread starter 7 years ago
#1
hi

so why does glucose need to be phosphorylated in gylcolysis?
why is it important?
would glycolysis be unable to continue if glucose wasn't phosphorylated?

btw im doing aqa A2 biology
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TFoulg
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Hi

The reasons we learned as to why this process is important is that phosphylation of Glucose to Glucose-6-Phosphate is that the transporters which diffuse Glucose in and out of a cell cannot perform this function on Glucose-6-Phosphate due to the negatively charged Phosphate being impermeable to the Plasma Membrane, which is important as it keeps the Glucose inside the cell where it's needed. Furthermore, the additional energy provided by the addition of the Phosphate group destabilises the molecule, which is necessary later on. This is because later on during Glycolysis another Phosphate molecule is added, and only then can the C bonds in the molecule be split.

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Commando1
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#3
Report Thread starter 7 years ago
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(Original post by TFoulg)
Hi

The reasons we learned as to why this process is important is that phosphylation of Glucose to Glucose-6-Phosphate is that the transporters which diffuse Glucose in and out of a cell cannot perform this function on Glucose-6-Phosphate due to the negatively charged Phosphate being impermeable to the Plasma Membrane, which is important as it keeps the Glucose inside the cell where it's needed. Furthermore, the additional energy provided by the addition of the Phosphate group destabilises the molecule, which is necessary later on. This is because later on during Glycolysis another Phosphate molecule is added, and only then can the C bonds in the molecule be split.

Hope this helped
ah ok thanks! are you doing AQA biology aswell?
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TFoulg
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#4
Report 7 years ago
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Yeah but I do Human Biology rather than Biology, but we cover the vast majority of the spec which is also related to our spec


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