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    I understand the process just a bit confused on one point; so siRNA is obtained and binds to Ris Complex. It then find homologous sequences to target for degradation- How is it possible for a strand to attract homologous strands ?
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    It doesn't "attract" a homologous strand, it's more of a trial and error process. The siRNA will contact many mRNA strands, but is only 100% complimentary to it's target mRNA. Once it finds this strand, siRNA will bind and be cut up by RISC.
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    did a coursework on this last month so I hope this helps.

    RNA interference is a conserved mechanism by which interference RNA (RNAi) specifically targets genes. A double-stranded RNA (dsRNA) such as viral RNA is exogenously introduced to the cell or microRNAs (miRNAs) that regulate gene expression are endogenously encoded. Exogenously introduced dsRNA is recognized by Dicer, a cytoplasmic ribonuclease that cleaves it into sequences called short interfering RNAs (siRNAs). Both siRNAs and miRNAs interact with a multi- protein RNA-induced silencing complex (RISC) that unwinds the RNA duplex and destroys one of the strands, known as the “passenger” strand. The remaining “guide” strand is used as a template to localize cellular mRNAs containing a homologous sequence. The degree of homology between the guide strand and the mRNA determines whether RISC initiates endonucleolytic cleavage or translational arrest of the target mRNA, thereby silencing expression of that gene.
 
 
 
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