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    • Thread Starter

    Hey guys,

    I'm confused with exactly what the role is for coenzymes and cofactors? And how do prosthetic groups come into play?

    Any help would be greatly appreciated!

    Cofactors are small molecules that some enzymes require for catalysis - they can be metal ions (like magnesium) or organic molecules (like ATP). Coenzymes are just organic cofactors. The coenzyme subcategory can be further split into prosthetic groups (coenzymes that are permanently bound to the enzyme) and cosubstrates (cofactors that enter the enzyme and then leave after the reaction).

    Basically, prosthetic groups are a kind of coenzyme, and coenzymes are a type of cofactor.
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