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For asthma and COPD we want to achieve a more local effect rather than systemic, for a systemic effect we'd target the alveolar sacs but for a local effect what would be the target location? Would it be the bronchi and bronchioles in the conducting zone?
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anyone?
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thegodofgod
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(Original post by tammie123)
For asthma and COPD we want to achieve a more local effect rather than systemic, for a systemic effect we'd target the alveolar sacs but for a local effect what would be the target location? Would it be the bronchi and bronchioles in the conducting zone?
Bronchi and bronchioles is correct. That is where sympathomimetics like salbutamol (short-acting beta2 adrenergic-receptor agonist) and salmeterol (long-acting beta2 adrenergic-receptor agonist) work, on the airway smooth muscles, causing them to relax by increasing synthesis of cAMP and, therefore, causing bronchodilation.

That is also where parasympatholytics like ipratropium (short-acting M3 muscarinic-receptor antagonist) and tiotropium (long-acting M3 muscarinic-receptor antagonist) work, although they work by decreasing the synthesis of IP3, and as such, limit smooth muscle contraction, and thus, reduce bronchoconstriction.

Hope this helps.
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