Something about Pharmaceutical EnzymesWatch this thread
Enzyme was first discovered by French chemist Anselme Payen in 1833. But it took a long time for the biochemical identity of enzymes. The conclusion that pure proteins can be enzymes was definitively demonstrated by John Howard Northrop and Wendell Meredith Stanley, who worked on the digestive enzymes pepsin (1930), trypsin and chymotrypsin. These three scientists were awarded the 1946 Nobel Prize in Chemistry.
Enzymes have been used for such a long time, and they are more and more popular. And the use of enzymes is almost without limits. Enzymes can be the tools of nature. They cut and paste products and speed up all vital biological process; Enzymes are also the warehouse of the body. When we eat, enzymes help the body to break down the food into tiny particles which can be converted into energy in the body.
One of the unique things about enzymes is that they have one function and one function only. Every function or substrate in an organism has its own unique enzyme. The substrate which is to be transformed fits the enzyme like a key in a lock. Only when the right enzyme finds the right substrate can biochemical reactions be happened.
What are Pharmaceutical Enzymes?
There have been numerous landmark achievements in drug design, especially during the past decades years with the development of new and improved therapeutic drugs for classes of compounds that did not exist previously. And the development of new drug has less toxicity and more specific benefits for people have been a major achievement. Since enzymes are widely used, they can also be used in pharmaceutical to help experts to discover more efficient drug. With enzymes help, drugs function can be activated and cause less toxicity. We can combine the pharmaceutical with biotechnology to synthesize new macromolecular drug entities.
Experts can get the protein drugs by isolating them from living systems. Because of recombinant DNA technology we can make macromolecular therapeutics such as insulin, growth hormone, monoclonal antibodies, and other proteins in highly purified form which makes them amenable to the general population.
How do Enzymes apply to drug?
Enzymes as drugs have two important features that distinguish them from all other types of drug. First, enzymes often bind and act on their targets with great affinity and specificity. Second, enzymes are catalytic and convert multiple target molecules to the desired products. These two features make enzymes specific and potent drugs that can accomplish therapeutic biochemistry in the body that small molecules cannot. These characteristics have resulted in the development of many enzyme drugs for a wide range of disorders.
Enzymes can speed up chemical reaction in living organisms. They come in all shapes and forms and catalyze all biological process, including protein synthesis and degradation, metabolic reactions, DNA synthesis and degradation, etc. and enzymes are prime drug target in the pharmaceutical industry, because enzymes are usually overactive and are relatively easy targets for small molecule inhibitor discovery.
Nowadays we have got a great achievement in Pharmaceutical Enzymes. Such as Aprotinin, HAase, Papain, Pepsin, Urease, etc. For more details, please come to Pharmaceutical Enzymes. We would be very glad to give to provide you any information you want to know.