Jaanu
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With a patient who has acute GI bleeding, why do they get hypotension by a blood transfusion?
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thegodofgod
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(Original post by Jaanu)
With a patient who has acute GI bleeding, why do they get hypotension by a blood transfusion?
They would get hypotension due to the blood loss, as the cardiac output would fall, but why would they get it after a blood transfusion?
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Joshalos
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(Original post by Jaanu)
With a patient who has acute GI bleeding, why do they get hypotension by a blood transfusion?
Acute hypotensive transfusion reaction is where the patient goes hypotensive during a blood transfusion, though this resolves on stopping the transfusion.

It is a result of bradykinin production from activation of Factor XII due to contact with negatively charged surfaces e.g. the plastic tubing or dialysis filters.
It is seen more so now with patients who take ACE inhibitors, since angiotensin converting enzyme metabolises bradykinin.
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Jaanu
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(Original post by Joshalos)
Acute hypotensive transfusion reaction is where the patient goes hypotensive during a blood transfusion, though this resolves on stopping the transfusion.

It is a result of bradykinin production from activation of Factor XII due to contact with negatively charged surfaces e.g. the plastic tubing or dialysis filters.
It is seen more so now with patients who take ACE inhibitors, since angiotensin converting enzyme metabolises bradykinin.
Thanks so much for replying! I was just wondering, while a patient is undergoing a blood transfusion,don't they come to a normal state from the hypotensive state as the blood volume is increasing?
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thegodofgod
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(Original post by Jaanu)
Thanks so much for replying! I was just wondering, while a patient is undergoing a blood transfusion,don't they come to a normal state from the hypotensive state as the blood volume is increasing?
Yes, that would make sense, as BP = CO x TPR, CO = cardiac output, TPR = total peripheral resistance.
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