Liver cells damanged by hepatitis infection switch on a gene called Fas, which causes them to self-destruct. Pioneering research has produced a strikingly successful treatment for hepatitis in mice. The Fas gene was silenced by the technique of RNA interference. RNA molecules, 21 to 23 nueclotides long, were injected into mice with hepatitis. The sequence of this 'small interfering RNA' (siRNA) matched part of the Fas gene. Once in the liver cell the two strands of the siRNA were seperated so that one strand could bind to the mRNA transcript of the Fas gene. This caused the mRNA to be destroyed by enzymes, therefore preventing the gene product from being made.
This therapy prevented liver cell death and considerably increased the survival of mice with hepatitis.
Describe how one strand of the siRNA can bind to the mRNA of the Fas gene.
Can anyone help please??
x Turn on thread page Beta
Biology help watch
- Thread Starter
- 02-11-2015 22:02