Hey there! Sign in to join this conversationNew here? Join for free
Turn on thread page Beta
    • Thread Starter

    how do CD4 and CD8 T cells bring about destruction of pancreatic B-cells?

    CD8 cells are 'cytotoxic' i.e they kill cells directly. Cells continuously expose fragments of protein on the outside of the plasma membrane via MHC 1 molecules.

    In a healthy state CD8 cells recognise the presented peptides as 'self'. Typically in a virally infected cell for example, part of protein fragments are chopped up and presented on the outside of the membrane via that MHC 1 molecule. CD8 then recognises the foreign protein and causes death of the infected cell. In some autoimmune conditions recognise 'self' as foreign and ultimately will kill healthy cells leading to necrosis.

    CD4 play a role in activating B cells which go on to produce antibodies. If the antibodies recognise parts of the healthy cell in a pathophysiological condition, it will cause activation of the complement system, subsequent opsonisation of the cell and ingestion of the cell via a phagocytic cell e.g a macrophage.
Submit reply
Turn on thread page Beta
TSR Support Team

We have a brilliant team of more than 60 Support Team members looking after discussions on The Student Room, helping to make it a fun, safe and useful place to hang out.

Updated: November 17, 2015
“Yanny” or “Laurel”

The Student Room, Get Revising and Marked by Teachers are trading names of The Student Room Group Ltd.

Register Number: 04666380 (England and Wales), VAT No. 806 8067 22 Registered Office: International House, Queens Road, Brighton, BN1 3XE

Write a reply...
Reputation gems: You get these gems as you gain rep from other members for making good contributions and giving helpful advice.