MMI example question help Watch

Medapplicant345
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“Liberation Therapy” (LT), a vascular operation developed to potentially cure multiple sclerosis (MS) in certain patients, has recently come under very serious criticism - delaying its widespread use. Among other experimental flaws, critics cite a small sample size in the original evidence used to support LT. As a healthcare policy maker, your job is to weigh the pros and cons in approving novel drugs and therapies. Please discuss the issues you would consider during an approval process for LT.
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Medapplicant345
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Could someone please help me with this question: 8. “Liberation Therapy” (LT), a vascular operation developed to potentially cure multiple sclerosis (MS) in certain patients, has recently come under very serious criticism – delaying its widespread use. Among other experimental flaws, critics cite a small sample size in the original evidence used to support LT. As a healthcare policy maker, your job is to weigh the pros and cons in approving novel drugs and therapies. Please discuss the issues you would consider during an approval process for LT
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Medapplicant345
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Hi i have an MMI interview at sheffield for medicine next Wednesday and was wondering if anyone could offer any advice? What to prepare with beforehand
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Hannah003
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(Original post by Medapplicant345)
“Liberation Therapy” (LT), a vascular operation developed to potentially cure multiple sclerosis (MS) in certain patients, has recently come under very serious criticism - delaying its widespread use. Among other experimental flaws, critics cite a small sample size in the original evidence used to support LT. As a healthcare policy maker, your job is to weigh the pros and cons in approving novel drugs and therapies. Please discuss the issues you would consider during an approval process for LT.
Did you manage to figure it out? because i'm doing mmi's and im stuck on this one too...
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The Medic Portal
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(Original post by Hannah003)
Did you manage to figure it out? because i'm doing mmi's and im stuck on this one too...
Hi there,

One of our doctors working with The Medic Portal suggests you think about the following:
There are two concepts to address: 1. Medical Ethics (see our free Application Guide on this to find out about four pillars!) and 2. Critiquing Evidence.

1. Use some of the principles of Medical Ethics, for example:

Beneficence (doing good): will delaying the useof this medication limit the good you can do for patients? This is potentiallycurative for MS and some patients may need this medication sooner rather thanlater.

Non-maleficence (not doing harm): drug trialshelp prevent patient safety issues by catching these earlier. If not doneproperly, a drug released on the market has the potential to cause serious harmif not taken through rigorous trials.

Justice: New therapies can be more expensive.Expensive therapies are limited on the NHS to certain patients. Will we able todeliver this therapy to all MS patients who need it, or limit its use tocertain MS patients because of the high cost of delivery. Is that just?

2. Critiquing evidence
For example:
- What type of trial was it? (randomised, singleblind, double blind?)
- What stage of MS were the cohort of patientsat?
- Were they on any other treatments at the time?
- Were any side effects recorded?
- Were these patients followed up over time toreview their response to the medication?
- Does the small sample size group limit theevidence?
- What are the statistical findings i.e. what isthe p-value of the evidence (particularly important with a small sample group)?

The fact that all these questions need to beasked perhaps support a conclusion that a repeat trial is needed with a largergroup of MS patients, but this depends on your findings when you critique theevidence.

We hope this helps!

The Medic Portal
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