How is high blood pressure bad and what actually is itWatch
How does high blood pressure result in someone having a thrombus and how does it work?
Hypertension can damage the endothelium in blood vessels and lead to the deposition of LDLs which in turn causes atherosclerosis, which I have explained on your other question. This can lead to coronary heart disease and angina pectoris which is pain in the chest due to lack of blood (and hence oxygen) reaching the heart muscle cells or cardiomyocytes. It can also lead to a heart attach/myocardial infarction, deep vein thrombosis and a pulmonary embolism.
A thrombus is essentially a blood clot within a blood vessel. So how does this relate to hypertension? As I mentionned, hypertension can lead to atherosclerosis. In atherosclerosis, smooth muscle cells migrate from the tunica media to the tunica intima and produce collagen which forms a fibrous capsule which surrounds the atheroma. Eventually, this fibrous capsule may rupture leaving collagen and other thrombogenic fragments from the fibrous capsule. This can cause thrombosis; platelets adhere to the fragments and activate the coagulation cascade leading to the formation of a blood clot/thrombus. These fragments can actually travel in the bloodstream and cause a blockage in sites distant from the site of rupture (embolism) and so it can also be called an embolus. For this reason, these fragments are called thrombo-emboli. These thrombo-emboli can travel to and block blood vessels in the brain which can cause stroke, and the coronary arteries which can cause a myocardial ininfarction.
Hopefully this helps.