Jennifer50
Badges: 4
Rep:
?
#1
Report Thread starter 4 years ago
#1
How does high blood pressure result in someone having a thrombus and how does it work?
0
reply
Jpw1097
Badges: 16
Rep:
?
#2
Report 4 years ago
#2
(Original post by Jennifer50)
How does high blood pressure result in someone having a thrombus and how does it work?
High blood pressure can be defined as a blood pressure greater than 140/80 mmHg. High blood pressure (hypertension) can be detrimental to health in may ways. Hypertension can cause damage to small capillaries in the body such as those in the retina and glomerulus (kidney) causing hypertensive retinopathy and hypertensive nephropathy respectively, which may lead to blindess and renal failure.

Hypertension can damage the endothelium in blood vessels and lead to the deposition of LDLs which in turn causes atherosclerosis, which I have explained on your other question. This can lead to coronary heart disease and angina pectoris which is pain in the chest due to lack of blood (and hence oxygen) reaching the heart muscle cells or cardiomyocytes. It can also lead to a heart attach/myocardial infarction, deep vein thrombosis and a pulmonary embolism.

A thrombus is essentially a blood clot within a blood vessel. So how does this relate to hypertension? As I mentionned, hypertension can lead to atherosclerosis. In atherosclerosis, smooth muscle cells migrate from the tunica media to the tunica intima and produce collagen which forms a fibrous capsule which surrounds the atheroma. Eventually, this fibrous capsule may rupture leaving collagen and other thrombogenic fragments from the fibrous capsule. This can cause thrombosis; platelets adhere to the fragments and activate the coagulation cascade leading to the formation of a blood clot/thrombus. These fragments can actually travel in the bloodstream and cause a blockage in sites distant from the site of rupture (embolism) and so it can also be called an embolus. For this reason, these fragments are called thrombo-emboli. These thrombo-emboli can travel to and block blood vessels in the brain which can cause stroke, and the coronary arteries which can cause a myocardial ininfarction.

Hopefully this helps.
0
reply
Jennifer50
Badges: 4
Rep:
?
#3
Report Thread starter 4 years ago
#3
Is cholesterol the same as ldl
0
reply
Jpw1097
Badges: 16
Rep:
?
#4
Report 4 years ago
#4
(Original post by Jennifer50)
Is cholesterol the same as ldl
Cholesterol is not the same as LDL. LDLs are large molecules which carry cholesterol and triglycerides.
0
reply
X

Quick Reply

Attached files
Write a reply...
Reply
new posts
Back
to top
Latest
My Feed

See more of what you like on
The Student Room

You can personalise what you see on TSR. Tell us a little about yourself to get started.

Personalise

Current uni students - are you thinking of dropping out of university?

Yes, I'm seriously considering dropping out (94)
13.78%
I'm not sure (32)
4.69%
No, I'm going to stick it out for now (214)
31.38%
I have already dropped out (16)
2.35%
I'm not a current university student (326)
47.8%

Watched Threads

View All