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    Describe the sequence of events which allows information to pass from one neurone to the next neurone across a cholinergic synapse.(5)

    My answer :
    An action potential arrives at the synaptic knob.
    This causes Ca+ ion channels to open and Ca+ ions rush into the synaptic knob
    The influx of Ca+ Ions cause synaptic vesicles to fuse with the pre-synaptic membrane and rupture
    The neurotransmitter is released from the vesicles into the synaptic cleft where it diffuses towards the post synaptic membrane
    The transmitter molecules (acetylcholine) binds to the receptor on the post synaptic membrane
    This causes sodium channels to open and Na+ ions rush in across the post synaptic membrane , against a concentraion gradient
    If the excitory post synaptic potential reaches the threshold, an action potential occurs in the post synaptic neurone
    Acetylcholinesterase breaks down the neurotransmitter in the synaptic cleft- acetylcholine is broken down into ethanoic acid and choline
    The products are reabsorbed by the synaptic knob and synthesised back into acetylcholine (using atp) which is stored in the synaptic vesicle.
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    (Original post by FREYA2898)
    Describe the sequence of events which allows information to pass from one neurone to the next neurone across a cholinergic synapse.(5)

    My answer :
    An action potential arrives at the synaptic knob.
    This causes Ca+ ion channels to open and Ca+ ions rush into the synaptic knob
    The influx of Ca+ Ions cause synaptic vesicles to fuse with the pre-synaptic membrane and rupture
    The neurotransmitter is released from the vesicles into the synaptic cleft where it diffuses towards the post synaptic membrane
    The transmitter molecules (acetylcholine) binds to the receptor on the post synaptic membrane
    This causes sodium channels to open and Na+ ions rush in across the post synaptic membrane , against a concentraion gradient
    If the excitory post synaptic potential reaches the threshold, an action potential occurs in the post synaptic neurone
    Acetylcholinesterase breaks down the neurotransmitter in the synaptic cleft- acetylcholine is broken down into ethanoic acid and choline
    The products are reabsorbed by the synaptic knob and synthesised back into acetylcholine (using atp) which is stored in the synaptic vesicle.
    It isn't against the concentration gradient.
    There's a higher concentration of Sodium outside of the axon because of the Na+/K+-ATPase which pumps Sodium out and Potassium in the axon.
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    (Original post by RMNDK)
    It isn't against the concentration gradient.
    There's a higher concentration of Sodium outside of the axon because of the Na+/K+-ATPase which pumps Sodium out and Potassium in the axon.
    Okay thank you x
 
 
 
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