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    I need some help answering these questionsName:  image.jpg
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    Looks like it is going on about diphosphoglycerate but is a bit confusing as in part 1 they call it DPH and in part 2 they are calling it DPG.
    DPG reduces Hb's affinity for o2 at lower po2 levels. This assists in the unloading of o2 from Hbo2 when pO2 is low eg in exercising muscles. It is part of the Bohr effect which is when the O2 dissociation curve is shifted to the right by increases in temperature, acidity or CO2 concentrations. Shifting the curve to the right means that for a given pO2, the %saturation of Hb with O2 is reduced, so O2 is offloaded and given to the active tissue.
    At altitude the pO2 levels are lower. The body responds to this in many ways. The main response is the release of erythropoetin which increases synthesis of new rbcs. This is what cyclists can cheat with, synthetic Epo injections to increase the O2 carrying capacity of the blood. Increased DPG at altitude will mean for a given pO2, the % sat of Hb with O2 will be less and this reduced affinity will mean more O2 is given to the respiring tissue.
 
 
 
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