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    • Thread Starter

    Does anyone know where I can find good explanations about HIV infection and ELISA? I am really confused about the whole thing right now
    Thankyou so much

    HIV infection - blood based infection, high rates of mutation, ssRNA retrovirus - primarily infects T cells via binding of gp120 to CD4 + CXCR4/CCR5. ssRNA genome is converted to DNA via reverse transcriptase, then integrated into the host cell genome with integrase. This results in the production of a variety of regulatory proteins like Tat/Rev/Nef, followed by the formation of a new HIV particle, and its release from the host cell.

    ELISA is the detection method, where patient serum samples are tested for antibody (Ab) titers against HIV - indirect and competitive ELISAs are both used.
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