Cambridge Chat (previously New Cambridge Students Entry 2004)

Watch
This discussion is closed.
crana9
Badges: 2
Rep:
?
#9381
Report 15 years ago
#9381
im still not convinced. how exactly would the lysosomes kill off the cell? they are well small compared to the cell, and if they all just released their contents, it wouldnt do anything because theyre only active in acid conditions.

It seems to mainly involve caspase protein cascades and not a mention of lysosomes.
0
Poc ar buile
Badges: 0
#9382
Report 15 years ago
#9382
My understanding (and I may well be wrong) was that signal molecules either from neighbouring cells or intracellularly come along and start a cascade reaction which would result in the membrane around the lysosome degrading and releasing the proteases, lipases and all the other nasties from the lysosome which degrade the cell. The problem I always had with that is, after nucleases degrade the genetic information the cell can do nothing to stop the runaway effects of the enzymes. This should destroy other cells once they get released into the tissue fluid. Maybe I'll ask KT when Eastenders is over!
0
visesh
Badges: 17
Rep:
?
#9383
Report 15 years ago
#9383
(Original post by crana9)
im still not convinced. how exactly would the lysosomes kill off the cell? they are well small compared to the cell, and if they all just released their contents, it wouldnt do anything because theyre only active in acid conditions.

It seems to mainly involve caspase protein cascades and not a mention of lysosomes.
Well I think my biology teacher mentioned something about some lysosomes containing inactive lytic enzymes which when exposed to the cytoplasm get are activated and kill the cell. It was a long time ago, and I was rather drunk at the time so feel free to ignore me.
0
crana9
Badges: 2
Rep:
?
#9384
Report 15 years ago
#9384
(Original post by polthegael)
My understanding (and I may well be wrong) was that signal molecules either from neighbouring cells or intracellularly come along and start a cascade reaction which would result in the membrane around the lysosome degrading and releasing the proteases, lipases and all the other nasties from the lysosome which degrade the cell. The problem I always had with that is, after nucleases degrade the genetic information the cell can do nothing to stop the runaway effects of the enzymes. This should destroy other cells once they get released into the tissue fluid. Maybe I'll ask KT when Eastenders is over!
well, as i just said, the lysosome nasties are only active in conditions of ~pH 5 which the cytosol is not.

I found this:

At one time, it was thought that lysosomes were responsible for killing cells scheduled to be removed from a tissue; for example, the resorption of its tail as the tadpole metamorphoses into a frog. This is incorrect. These examples of programmed cell death (PCD) or apoptosis take place by an entirely different mechanism. Link to a discussion of apoptosis.

from
http://users.rcn.com/jkimball.ma.ult...Lysosomes.html


hence i conclude this was yet another A-Level Lie

i may assemble a collection of these and post them to my teacher. or not, of course.
0
KHL
Badges: 0
Rep:
?
#9385
Report 15 years ago
#9385
(Original post by polthegael)
My understanding (and I may well be wrong) was that signal molecules either from neighbouring cells or intracellularly come along and start a cascade reaction which would result in the membrane around the lysosome degrading and releasing the proteases, lipases and all the other nasties from the lysosome which degrade the cell. The problem I always had with that is, after nucleases degrade the genetic information the cell can do nothing to stop the runaway effects of the enzymes. This should destroy other cells once they get released into the tissue fluid. Maybe I'll ask KT when Eastenders is over!
http://www.ucalgary.ca/UofC/eduweb/v...ath_intro.html

you'll be getting quite a bit about apoptosis next year as part of IB medic/bionatsci pathology.

and btw, it was originally coined as apo-ptosis, so it's pronounced a-po-to-sis. (2nd p is silent. though everyone nowadays seems to pronounce it other than poor old prof wyllie, who, incidentally, coined that term.)

and the beauty of proteases and other lytic enzymes are that they are catalysts, i.e. not consumed in reactions, so relatively small amounts of these nasties are more than able to digest large chunks of the cell if released from lysosomes.
0
Katie J
Badges: 10
Rep:
?
#9386
Report 15 years ago
#9386
(Original post by androidkiller)
Dammit. Medics get such better practicals.
Hello (it really annoys me now that there are certain people I would have met with or without this website, not sure why it should annoy me but it does!)

Our practicals are all voluntary, I think the arch & anth staff are scared if they even mention science everyone will run away!! :mad:

I did an erg thing today, apparently I'm not rubbish afterall despite not having any coordination! My foot hurts even more though and now it's going sort of blue underneath, stupid foot, I haven't done anything to it!! :confused:
0
priya
Badges: 14
Rep:
?
#9387
Report 15 years ago
#9387
(Original post by Katie J)
Hello (it really annoys me now that there are certain people I would have met with or without this website, not sure why it should annoy me but it does!)

Our practicals are all voluntary, I think the arch & anth staff are scared if they even mention science everyone will run away!! :mad:

I did an erg thing today, apparently I'm not rubbish afterall despite not having any coordination! My foot hurts even more though and now it's going sort of blue underneath, stupid foot, I haven't done anything to it!! :confused:
argh i have to go on the ergs for about 30 mins at some point between now and tuesday...rowing at 7am on tuesday, fun fun fun
0
Katie J
Badges: 10
Rep:
?
#9388
Report 15 years ago
#9388
(Original post by priya)
argh i have to go on the ergs for about 30 mins at some point between now and tuesday...rowing at 7am on tuesday, fun fun fun
Went today at 6:30am and tomorrow at 6:30am!! :eek:
I didn't know what I was letting myself in for when I signed up, I thought novicing was just nice little splashing abouts in boats on Sunday afternoons! I wasn't expecting to have to do anything training wise or stretching other than the basic teaching!! I also wasn't expecting my right foot to randomly rebel against me!!
0
priya
Badges: 14
Rep:
?
#9389
Report 15 years ago
#9389
(Original post by Katie J)
Went today at 6:30am and tomorrow at 6:30am!! :eek:
I didn't know what I was letting myself in for when I signed up, I thought novicing was just nice little splashing abouts in boats on Sunday afternoons! I wasn't expecting to have to do anything training wise or stretching other than the basic teaching!! I also wasn't expecting my right foot to randomly rebel against me!!
my plan is to row for a term, buy the ssbc hoodie, and then wear it for the next 3 years. but possibly discontinue rowing if it all gets too much. most of the people in my college have done this lol
0
crana9
Badges: 2
Rep:
?
#9390
Report 15 years ago
#9390
has anyone else noticed this trend for everyone to be wearing "leavers hoodies" from their school? i find it all quite odd
0
Katie J
Badges: 10
Rep:
?
#9391
Report 15 years ago
#9391
(Original post by crana9)
has anyone else noticed this trend for everyone to be wearing "leavers hoodies" from their school? i find it all quite odd
We didn't get leavers' hoodies

Piyra, I have a friend only in the rowing scene for the scary lycra suits!! She's a little strange...
0
visesh
Badges: 17
Rep:
?
#9392
Report 15 years ago
#9392
(Original post by crana9)
has anyone else noticed this trend for everyone to be wearing "leavers hoodies" from their school? i find it all quite odd
I get a leaver's tie from mine. And £500 apparently.
0
crana9
Badges: 2
Rep:
?
#9393
Report 15 years ago
#9393
even had we had the option to have one i dont think i would have fone
0
visesh
Badges: 17
Rep:
?
#9394
Report 15 years ago
#9394
(Original post by crana9)
even had we had the option to have one i dont think i would have fone
Excuse me?
0
crana9
Badges: 2
Rep:
?
#9395
Report 15 years ago
#9395
(Original post by visesh)
Excuse me?
done. not fone.
with regards to hoodies
0
visesh
Badges: 17
Rep:
?
#9396
Report 15 years ago
#9396
(Original post by crana9)
done. not fone.
with regards to hoodies
Ahhh thanks.

If anyone sees someone with a Black NHS(or maybe Nottingham High School) Cross country hoodie, say hi to him from me. Medic at Catz.
0
Camford
Badges: 12
Rep:
?
#9397
Report 15 years ago
#9397
Damn it!! I need bread and ham!! They are running out on me!! Sainsbury's I'm coming to get you!!!
0
visesh
Badges: 17
Rep:
?
#9398
Report 15 years ago
#9398
(Original post by Camford)
Damn it!! I need bread and ham!! They are running out on me!! Sainsbury's I'm coming to get you!!!
Go then. Leave us alone.
0
crana9
Badges: 2
Rep:
?
#9399
Report 15 years ago
#9399
(Original post by Camford)
Damn it!! I need bread and ham!! They are running out on me!! Sainsbury's I'm coming to get you!!!
shuai, if you do gho to sainsburys (you have 22 minutes) can you get me a 2 pint of semi please , ill pay you back . (its 58p )

i poured some in my tea earlyer and then realised it was in solid lumps
0
Camford
Badges: 12
Rep:
?
#9400
Report 15 years ago
#9400
(Original post by crana9)
shuai, if you do gho to sainsburys (you have 22 minutes) can you get me a 2 pint of semi please , ill pay you back . (its 58p )

i poured some in my tea earlyer and then realised it was in solid lumps
I bunked the comp room after I send off my post. Didn't know you wanted milk... Sorry. maybe next time. But I got the bread though. So, if you want your 7 slices of bread back, now is the time.
0
X
new posts
Back
to top
Latest
My Feed

See more of what you like on
The Student Room

You can personalise what you see on TSR. Tell us a little about yourself to get started.

Personalise

If you're planning on going to uni this year, would any of these financial reasons stop you?

Not being able to work now to save up for uni (92)
14%
Reduced household income due to coronavirus means I can't afford to go (54)
8.22%
Lack of part-time jobs to support me while I'm at uni (84)
12.79%
Lack of graduate job prospects when I finish uni (79)
12.02%
Other reasons are stopping me going (84)
12.79%
Nothing is stopping me going (264)
40.18%

Watched Threads

View All