I have a very detailed reply for you from one of our really fantastic ambassadors. I hope it helps

Hi! I’m just about to start my third year studying the Biochemistry course at Oxford, having starting in October 2015. From what you’ve said and from my experience of the Biochemistry course, and my impression of the Biology course here from friends, I would say applying for Biochemistry sounds like a good choice if it’s the molecular aspect of biology you enjoy!
In terms of the chemistry-orientation, it’s true this was a big part of first year. One of our five first-year exam papers was solely Organic Chemistry and I found this quite tough and a big jump from how I found chemistry at sixth form (I did the OCR A-Level syllabus A). The questions I faced in my two interviews for Biochemistry at Oxford were also much more heavily weighted towards topics from my Chemistry studies at sixth-form than my Biology studies. I would say the ‘Biophysical Chemistry’ in the first-year Oxford Biochmistry course was also more chemistry-oriented in relation to my sixth-form Chemistry studies in terms of the concepts covered (e.g. rates of reaction, equilibria, enthalpy, entropy, free energy, inter- and intramolecular bonding, covalent and non-covalent interactions, transition metal ions). However, the chemical/physical/thermodynamic/kinetic principles were all presented in a molecular biology context – e.g. in relation to what drives protein folding, enzyme mechanisms and their reactions within cells.
I would also say a big chunk of our first-year course encompassed a lot more directly molecular biology-oriented topics. These were mainly in ‘Biological Chemistry’ and ‘Molecular Cell Biology’ and included
- protein structure, function and folding
- enzymes, their reactions, mechanisms and regulation
- DNA and RNA structure, storage and replication, transcription and translation, mutations and repair (we actually shared our genetics lectures in the first term with first year Biology students)
- biological membranes architecture (the proteins and lipids) and transport
- metabolism – reaction pathways, cycles and mechanisms, how they’re regulated and diseases associated with faults in these pathways or processes – including:
o glycolysis, the tricarboxylic acid (TCA, or Krebs) cycle and mitochondrial electron transport chain in respiration
o the light reactions and dark reactions (Calvin cycle) in photosynthesis
o fatty acid synthesis and degradation
o amino acid metabolism
- cell structure and division (including the roles of different organelles and the cytoskeleton)
- signalling pathways for communication between and within cells
I would say the second-year course has involved delving into these topics introduced in first-year Biological Chemistry and Molecular Cell Biology in even more molecular detail. Although we’ve needed the chemistry-oriented principles we learned in first-year Biophysical Chemistry for this, there has been nothing as solely chemistry-oriented as the first-year Organic Chemistry.
I hope that all makes sense – since you mentioned the online course overview, a lot what I’ve talked about relates to that, in particular the five strands of the first-year course (
https://www.ox.ac.uk/admissions/undergraduate/courses-listing/biochemistry-molecular-and-cellular?wssl=1). If you can get a sense of whether a similar level of molecular biology is included in the Oxford Biological Sciences course that may also be useful. If you decide to apply for Biochemistry, can I just say that we have two great tutors at LMH - Phil Biggin (our main tutor, also a lecturer for the biochemistry course) and Garry Brown (who we share with the medics at LMH, and who has taken us for metabolism- and genetics-related tutorials). They are both very approachable and friendly and extremely knowledgeable and passionate about their subjects!
