Girl shaking my hand Watch
PS: I'm a woman and can assure you we don't get uncomfortable in shaking a man/woman's hand.
This is a totally unisex custom. For any woman or man you don't know well, a handshake is an appropriate greeting. The only exception is for very personal situations, like meeting extended family.
I met this girl Yesterday at an event as she was part of a group I was with although it was the first occasion on which I had spoken to her directly, After introducing myself she wanted to shake my hand, I've never done this with women as I am not sure if they are comfortable with it. Does this meaning anything though as I found this unusual?