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    Need help with Bioinformatics please?! I'm using Uniprot to investigate mutations in accession code P04156. I'm finding it all a bit confusing.
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    It might help if you have a specific question so someone can talk you through what you're stuck with.
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    (Original post by alleycat393)
    It might help if you have a specific question so someone can talk you through what you're stuck with.
    i'm comparing the predicted effects of the mutations to PolyPhen2 results to determine the disease causing/preventing variants. Can you point me in the right direction?
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    (Original post by Xhetart)
    i'm comparing the predicted effects of the mutations to PolyPhen2 results to determine the disease causing/preventing variants. Can you point me in the right direction?
    And what have you found/what are you stuck with? No one is going to do this for you. You've got the protein up and have found these mutations? Think about how they may affect structure and function.
 
 
 
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