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    How does T killer cells secreting chemicals that make holes in cell membrane, cause a cell to die?
    please help, thankyou!
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    (Original post by didi1011)
    How does T killer cells secreting chemicals that make holes in cell membrane, cause a cell to die?
    please help, thankyou!
    I'm not sure exactly what level you require..

    There are two main proteins secreted by the T-killer cells: perforins and granzymes

    Perforins are those that youd described, they make a hole or pore in the plasma membrane.

    These pores allows granzymes to diffuse into the cell.

    Granzymes are proteases that will destroy cellular contents of pathogens, e.g. proteins made by a virus.
    But more importantly, these Granzymes activate another protein in the cell called Caspases. The Caspases are the ones that carry out apoptosis.

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    (Original post by didi1011)
    How does T killer cells secreting chemicals that make holes in cell membrane, cause a cell to die?
    please help, thankyou!
    Since cells are all about storing chemicals in concentrations far higher than the outside abiotic world, the holes in the cell surface membrane will cause the loss of valuable nutrients like glucose, as well of essential organelles like ribosomes, and, most importantly, DNA/RNA.

    However, according to https://en.wikipedia.org/wiki/Perforin , proteases diffuse into the cell via these pores and they're what really kill the cell by destroying it.
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    (Original post by telepathicnine)
    I'm not sure exactly what level you require..

    There are two main proteins secreted by the T-killer cells: perforins and granzymes

    Perforins are those that youd described, they make a hole or pore in the plasma membrane.

    These pores allows granzymes to diffuse into the cell.

    Granzymes are proteases that will destroy cellular contents of pathogens, e.g. proteins made by a virus.
    But more importantly, these Granzymes activate another protein in the cell called Caspases. The Caspases are the ones that carry out apoptosis.

    Ah, you beat me to it
 
 
 
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