avsl020
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The AQA biology textbook says that oestrogen binds to a transcription factor which initiates transcription, however it later states that oestrogen releases a chemical which inhibits transcription leading to cancer. Can someone explain this please?
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Hajra Momoniat
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Oestrogen can initiate the transcription of target genes. NB: Sometimes it can cause a transcription factor to be a repressor. You don’t need to know this for the AQA exam. A transcription factor may be bound to an inhibitor stopping it from binding to the promoter sequence. Oestrogen binds to the transcription factor making an oestrogen-oestrogen receptor complex and changes the site where the inhibitor is joined on (called DNA binding site). This means that the inhibitor is detached allowing the transcription factor to attach to the promoter sequence. NB: You don’t need to know the name of the inhibitor. Also the DNA binding site on the transcription factor stays changed whilst the oestrogen has bound to it.

Hope this helps
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