Oestrogen in transcription? Watch

avsl020
Badges: 1
Rep:
?
#1
Report Thread starter 1 year ago
#1
The AQA biology textbook says that oestrogen binds to a transcription factor which initiates transcription, however it later states that oestrogen releases a chemical which inhibits transcription leading to cancer. Can someone explain this please?
Thanks
0
reply
Hajra Momoniat
Badges: 14
Rep:
?
#2
Report 1 year ago
#2
Oestrogen can initiate the transcription of target genes. NB: Sometimes it can cause a transcription factor to be a repressor. You don’t need to know this for the AQA exam. A transcription factor may be bound to an inhibitor stopping it from binding to the promoter sequence. Oestrogen binds to the transcription factor making an oestrogen-oestrogen receptor complex and changes the site where the inhibitor is joined on (called DNA binding site). This means that the inhibitor is detached allowing the transcription factor to attach to the promoter sequence. NB: You don’t need to know the name of the inhibitor. Also the DNA binding site on the transcription factor stays changed whilst the oestrogen has bound to it.

Hope this helps
0
reply
X

Quick Reply

Attached files
Write a reply...
Reply
new posts
Latest
My Feed

See more of what you like on
The Student Room

You can personalise what you see on TSR. Tell us a little about yourself to get started.

Personalise

University open days

  • Cardiff University
    Undergraduate Open Day Undergraduate
    Wed, 27 Mar '19
  • University of Portsmouth
    Postgraduate and Part-Time Open Evenings Postgraduate
    Wed, 27 Mar '19
  • Middlesex University London
    Postgraduate Open Evening Postgraduate
    Wed, 27 Mar '19

How old were you when you first saw porn?

I've never seen it (207)
22.7%
Before I was 12 (323)
35.42%
13 (147)
16.12%
14 (108)
11.84%
15 (56)
6.14%
16 (34)
3.73%
17 (11)
1.21%
18 (8)
0.88%
Between the ages of 19 - 25 (13)
1.43%
Over 25 (5)
0.55%

Watched Threads

View All
Latest
My Feed

See more of what you like on
The Student Room

You can personalise what you see on TSR. Tell us a little about yourself to get started.

Personalise