It depends - are you thinking of doing a Business or Languages degree at university?
Most universities mainly focus on the grades you receive for A-Level and the core GCSE subjects (Maths, English and Science), and as far as I'm aware, Cambridge has no GCSE requirements except for its medicine and dentistry courses.
It does matter if you want to go to a top university (you need almost all A*s, unless you have a really good interview), but with less prestigious universities it should be fine as long as you don't take the subject.