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    Why is Paracetamol not very soluble in water even though it can form hydrogen bonds with water?
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    (Original post by Mileskingman)
    Why is Paracetamol not very soluble in water even though it can form hydrogen bonds with water?
    The structure of paracetamol has an aromatic ring as part of its' structure. Aromatic rings are very non-polar and therefore hydrophobic. This will dominate the solubility characteristics of the compound, making paracetamol only sparingly soluble in water (i.e. almost completely insoluble)
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    (Original post by Mileskingman)
    Why is Paracetamol not very soluble in water even though it can form hydrogen bonds with water?
    Paracetamol as the name reveals has an aromatic ring, the phenol to be exact. This one has the OH-group, thanks to this functional group paracetamol is hygroscopic, that is to say it binds water, so much that this substance cannot be solved in water.
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    Kallisto
    TutorsChemistry

    Thank you both very much for your help. They both have explained it.
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    (Original post by Mileskingman)
    Kallisto
    TutorsChemistry

    Thank you both very much for your help. They both have explained it.
    You are welcome. And thanks for your feedback, that means a lot to me and appreciate it. Most I gave an answer did not reply to thank.
 
 
 
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