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    Hi,

    I am currently writing an essay for an access course and one of the things I have to include is,
    • The generation of specialised tissues from embryonic stem cells.
    I have searched the interent for this but just really dont understand what it means.
    Can anyone help? :/
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    I think it means how embryonic stem cells turn into specialised tissues
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    (Original post by kelly-grace)
    Hi,

    I am currently writing an essay for an access course and one of the things I have to include is,
    • The generation of specialised tissues from embryonic stem cells.
    I have searched the interent for this but just really dont understand what it means.
    Can anyone help? :/
    Do you know what a stem cell is firstly? that'll make it easier to understand what's expected of you!
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    Very broad topic. Embryonic stem cells differentiate into different cell types, usually in several stages, before becoming "committed" to a cell fate. It requires specific extracellular signals and transcription factors need to be expressed in specific patterns to bring it about. I'd probably try and find a few examples and go with those.

    From a lab I worked in, I know differentiation of P19 carcinoma cells and iPSC's into motor neurons has been widely done (I used to work in an ALS lab). A way to transform alpha cells in the pancreas to beta cells has been devised....so I assume they've worked out how to generate them from stem cells. These are two big areas (instead of something that may be more niche, like...muscles?) so could be good starting points.

    I focused on Developmental biology in my just completed Masters degree, so let me know if I can help.
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    (Original post by QuentinM)
    Very broad topic. Embryonic stem cells differentiate into different cell types, usually in several stages, before becoming "committed" to a cell fate. It requires specific extracellular signals and transcription factors need to be expressed in specific patterns to bring it about. I'd probably try and find a few examples and go with those.

    From a lab I worked in, I know differentiation of P19 carcinoma cells and iPSC's into motor neurons has been widely done (I used to work in an ALS lab). A way to transform alpha cells in the pancreas to beta cells has been devised....so I assume they've worked out how to generate them from stem cells. These are two big areas (instead of something that may be more niche, like...muscles?) so could be good starting points.

    I focused on Developmental biology in my just completed Masters degree, so let me know if I can help.
    Thank you so much for your help on this. It`s very helpful. Im just getting strarted on biology, (I`m hoping to do a nursing degree), so I will be sure to let you know if I come stuck again. :gthumb::thumbsup:
 
 
 
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