Its hard and painful but eventually you adjust to a life of being lonely.
Its hard and bitter to your self esteem to have lunch and dinner alone everyday day, no one to ask questions about your day or laugh at your jokes.
No external validation that boosts your self esteem.
With the internet and growing hook up culture, its harder and harder for average lookings guys to meet girls.
Especially if your starting from a position of no female friends, you wont be meeting girls on a regular basis
Your essentially cut off from the dating pool