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University coursework help!!!

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(edited 6 years ago)
Original post by Jack98_
“What force generating motors are involved in vesicles trafficking in cells? How do vesicles interact with such motors?”


What research have you already done around this and what are you stuck with?
Original post by Jack98_
Motor proteins bind to either microtubules or microfilaments and move along the strand, normally when joined to some type of cargo ie organelle, membrane or vesicle. In walking along the various tracks, they utilise ATP to generate movement. Microtubules have two classes of motor proteins, kinesins and dyneins and microfilaments use the motor protein myosin. Intermediate filaments do not have motor proteins.



Kinesin is a small motor protein and moves bound cargo toward the plus end of the microtubule by a hand over hand movement which means it is always bound to the track. Vesicles require a kinesin binding protein, kinectin, in its membrane to secure it on.



Dynein is huge and moves towards the microtubule’s negative end, thus moves cargo in toward the cell centre, opposite to kinesin. The cargo requires a complex called dynactin in its membrane in order to bind the light chain of dynein. Movement along the microtubule is generated by the activity of ATPase.


This is really well written and researched so well done! I would add maybe some info about the relative sizes of the various motor proteins and the vesicles and if you can find any info about the number of ATP molecules required to move a vesicle maybe a fixed distance.
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G-Sci
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Original post by Jack98_
Motor proteins bind to either microtubules or microfilaments and move along the strand, normally when joined to some type of cargo ie organelle, membrane or vesicle. In walking along the various tracks, they utilise ATP to generate movement. Microtubules have two classes of motor proteins, kinesins and dyneins and microfilaments use the motor protein myosin. Intermediate filaments do not have motor proteins.



Kinesin is a small motor protein and moves bound cargo toward the plus end of the microtubule by a hand over hand movement which means it is always bound to the track. Vesicles require a kinesin binding protein, kinectin, in its membrane to secure it on.



Dynein is huge and moves towards the microtubule’s negative end, thus moves cargo in toward the cell centre, opposite to kinesin. The cargo requires a complex called dynactin in its membrane in order to bind the light chain of dynein. Movement along the microtubule is generated by the activity of ATPase.


Have a search on pubmed too for a recently published paper to have some really up to date stuff there, lecturers always love that!

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