Turn on thread page Beta
    • Thread Starter
    Offline

    2
    ReputationRep:
    we did an experiment to observe 50 % narcosis in Tetrahymena pyriformis and there is a question which is asking to explain the slope on the graph, the graph shows that Methanol needed a high concentration to produce 50% narcosis and Butanol needed smaller concentration to produce 50% narcosis, the question is to relate this to the actual structure of the alcohols with respect to their permeability and the structure of the membrane. I could do with some help Please?
    Offline

    15
    ReputationRep:
    Butanol has a longer carbon backbone, and so is more similar to the phospholipid bi-layer of the cell membrane. And therefore more permeable, so lower concentrations are required to achieve 50% narcosis.
    Online

    11
    ReputationRep:
    (Original post by Aimee 2018)
    we did an experiment to observe 50 % narcosis in Tetrahymena pyriformis and there is a question which is asking to explain the slope on the graph, the graph shows that Methanol needed a high concentration to produce 50% narcosis and Butanol needed smaller concentration to produce 50% narcosis, the question is to relate this to the actual structure of the alcohols with respect to their permeability and the structure of the membrane. I could do with some help Please?
    For a drug to cause narcosis, it must cross the blood-brain barrier (BBB), which is made up of various cell membranes. Methanol (CH3OH) is more polar, making it more hydrophilic (or lipophobic), and therefore it will find it more difficult to cross the BBB. Butalon (CH3CH2CH2CH2OH) is less polar making it more hydrophobic (lipophilic) and therefore it will find it much easier to cross the BBB and cause achieve narcosis.
 
 
 
Reply
Submit reply
Turn on thread page Beta
Updated: March 4, 2018

University open days

  1. University of Bradford
    University-wide Postgraduate
    Wed, 25 Jul '18
  2. University of Buckingham
    Psychology Taster Tutorial Undergraduate
    Wed, 25 Jul '18
  3. Bournemouth University
    Clearing Campus Visit Undergraduate
    Wed, 1 Aug '18
Poll
How are you feeling in the run-up to Results Day 2018?

The Student Room, Get Revising and Marked by Teachers are trading names of The Student Room Group Ltd.

Register Number: 04666380 (England and Wales), VAT No. 806 8067 22 Registered Office: International House, Queens Road, Brighton, BN1 3XE

Write a reply...
Reply
Hide
Reputation gems: You get these gems as you gain rep from other members for making good contributions and giving helpful advice.