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    could someone explain me about the blood clotting cascade?
    I get confused on thromboplastin, prothromboplastin and thrombin.

    Any help appreciated

    thanks
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    Sorry you've not had any responses about this. Are you sure you've posted in the right place? Here's a link to our subject forum which should help get you more responses if you post there.
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    (Original post by TSR Jessica)
    Sorry you've not had any responses about this. Are you sure you've posted in the right place? Here's a link to our subject forum which should help get you more responses if you post there.
    well, at least you replied aha

    I dont think many people like about blood clotting cascade tbh
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    (Original post by letsrespire)
    could someone explain me about the blood clotting cascade?
    I get confused on thromboplastin, prothromboplastin and thrombin.

    Any help appreciated

    thanks

    Most exam boards want you to know the tissue activated cascade, which goes like this:

    1) Damaged tissue exposes collagen fibres which activates thromboxane causing platlets to aggregate at the wound.

    2) Leucocytes gather to the wound and cause the endothelium to release Thromboplastin.

    3) Thromboplatin (an enzyme) catalyses prothrombin (inactive protein) to thrombin (active enzyme). This process needs calcium ions.

    4) The now active Thrombin catalyses Fribrinogen (soluble) to Fribrinogen (INsoluble). This also needs calcium ions.

    5) Fribrin fibres form a mesh over the wound causing a clot.

    Hope this helps!
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    (Original post by Bob man)
    Most exam boards want you to know the tissue activated cascade, which goes like this:

    1) Damaged tissue exposes collagen fibres which activates thromboxane causing platlets to aggregate at the wound.

    2) Leucocytes gather to the wound and cause the endothelium to release Thromboplastin.

    3) Thromboplatin (an enzyme) catalyses prothrombin (inactive protein) to thrombin (active enzyme). This process needs calcium ions.

    4) The now active Thrombin catalyses Fribrinogen (soluble) to Fribrinogen (INsoluble). This also needs calcium ions.

    5) Fribrin fibres form a mesh over the wound causing a clot.

    Hope this helps!
    this is SO helpful! thank you
 
 
 

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