what's the difference between epigenetics and the diathesis stress model?

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BPBPBPBP
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#1
Report Thread starter 3 years ago
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I was thinking about that (title Q), did a search on google which pointed to, early on in the list, a post on this forum:

https://www.thestudentroom.co.uk/sho....php?t=4795320
epigenetics is when the environment physically changes the structure of your genes. Diathesis stress model is a theory that states (im assuming youre doing sz) to have Sz you first must have a diathesis or genetic basis and then a stressor which causes Sz to manifest itself

That didn't ring right. I was and still am under the impression that epigentics is like a modifiyer, editor, filter in the gene expression processing, inbetween the genes and final phenotype expression. And a google for epigenetics, the google provided definition:

the study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself.

So what I thought epigenetics is is right. And that is absolutely contrary to what's in that post on here I linked to.

So, what is the difference between epigenetics and the diathesis stress model?

I'm wondering if they are basically the same thing? But the diathesis stress model is a more particular, specific example/version of epigenetics maybe? I think the diathesis stress is about how a disease/problem gets expressed, whereas epigenetics is just about the whole general idea of how something goes inbetween genes and their expression, and that that something modifies gene expression (without modifying the genes).

edit: so the diathesis stress model is a subset of epigenetics?
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Findlay6
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#2
Report 3 years ago
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Epigenetics.
The idea that external events physically alter genetic coding which can be passed on. Eg, pollution or exercise

Diathesis stress
The idea that we have genetic vulnerability to all illness but this only develops if triggered by the right environmental stressor.
Eg, mum has depression, you have an increased chance of developing it but you won't unless you experience a certain situation.
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BPBPBPBP
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#3
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OK, great, thanks for that.

The epigenetics explanation though, you've left out whether it changes genes themselves or just the expression of the genes. The google def said it doesn't affect genes themselves, only the expression. And I'm sure I've read some pretty detailed explanation of epigentics some time ago which said the same thing.

I'm not convinced they're not basically the same thing. Apart from diathesis stress talks about a particular kind of expression, an illness, eg depression.

Both are about external events affecting final gene expression. I think that's established. And if I'm right, which I'm pretty sure I am, both are about how the expression of genes gets modified, between the genes themselves and the final expression.

It's just that the daithesis stress version concentrates on depression and schizophrenia, whereas epigentics includes those things, but also many other things, including non-disease stuff.
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kitney
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#4
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(Original post by BPBPBPBP)
OK, great, thanks for that.

The epigenetics explanation though, you've left out whether it changes genes themselves or just the expression of the genes. The google def said it doesn't affect genes themselves, only the expression. And I'm sure I've read some pretty detailed explanation of epigentics some time ago which said the same thing.

I'm not convinced they're not basically the same thing. Apart from diathesis stress talks about a particular kind of expression, an illness, eg depression.

Both are about external events affecting final gene expression. I think that's established. And if I'm right, which I'm pretty sure I am, both are about how the expression of genes gets modified, between the genes themselves and the final expression.

It's just that the daithesis stress version concentrates on depression and schizophrenia, whereas epigentics includes those things, but also many other things, including non-disease stuff.
To add to your response, I've also read one can carry genes for diseases, even autoimmune diseases. However, it is only when the individual experiences an increase in stress (i.e. trauma, decrease in support, increase in dysfunction) or is exposed to an environmental chemical (i.e. fetus exposed to alcohol, PKU gene carrier exposed to phenylalanine) then does the gene turn on to present phenotypically in a physiological and/or psychological form. I agree that epigenetics and the diathesis-stress model seem to follow the same process. However, it does seem that epigenetics can be influenced by positive factors too. "The epigenome can be affected by positive experiences, such as supportive relationships and opportunities for learning, or negative influences, such as environmental toxins or stressful life circumstances, which leave a unique epigenetic “signature” on the genes. These signatures can be temporary or permanent and both types affect how easily the genes are switched on or off." (https://developingchild.harvard.edu/...%20the%20genes.)
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