Tmkz
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What are the specific sites of absorption of vitamins? I know vitamin k is absorbed in the large intestine and B12 in the ileum and that's about it.
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Mariaa_bxx
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(Original post by Tmkz)
What are the specific sites of absorption of vitamins? I know vitamin k is absorbed in the large intestine and B12 in the ileum and that's about it.
Have you got the OCR 2017 papers?
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macpatgh-Sheldon
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Hi,

Sorry you have not had a relevant reply yet - let me try to help.

You are correct that B12 is absorbed across the ileal mucosa - this process requires a protein, called intrinsic factor, secreted by the gastric parietal cells. Deficiency of intrinsic factor leads to pernicious anaemia [a type of macrocytic anaemia [with large erythrocytes]].

The fat soluble vitamins (A, D, E and K) are absorbed with fats as micelles after conversion to esters. Any disease that reduces bile secretion or blocks the bile duct reduces their absorption [bile is needed for emulsification of fats].

Vitamins B1 (thiamine), B2 (riboflavine), niacin, B6 (pyridoxine) and ascorbic acid (vitamin C) are sodium-dependent as they are absorbed by Na+ cotransporters (mostly in the duodenum). Vitamin B12 and folate absorption do not require sodium.

Thanks,
M
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Tmkz
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(Original post by Mariaa_bxx)
Have you got the OCR 2017 papers?
Nope and I can't see them on the ocr website, have you seen a question like this in that paper?
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Tmkz
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(Original post by macpatelgh)
Hi,

Sorry you have not had a relevant reply yet - let me try to help.

You are correct that B12 is absorbed across the ileal mucosa - this process requires a protein, called intrinsic factor, secreted by the gastric parietal cells. Deficiency of intrinsic factor leads to pernicious anaemia [a type of macrocytic anaemia [with large erythrocytes]].

The fat soluble vitamins (A, D, E and K) are absorbed with fats as micelles after conversion to esters. Any disease that reduces bile secretion or blocks the bile duct reduces their absorption [bile is needed for emulsification of fats].

Vitamins B1 (thiamine), B2 (riboflavine), niacin, B6 (pyridoxine) and ascorbic acid (vitamin C) are sodium-dependent as they are absorbed by Na+ cotransporters (mostly in the duodenum). Vitamin B12 and folate absorption do not require sodium.

Thanks,
M
Thank you very much! This was very useful
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Tmkz
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(Original post by macpatelgh)
Hi,

Sorry you have not had a relevant reply yet - let me try to help.

You are correct that B12 is absorbed across the ileal mucosa - this process requires a protein, called intrinsic factor, secreted by the gastric parietal cells. Deficiency of intrinsic factor leads to pernicious anaemia [a type of macrocytic anaemia [with large erythrocytes]].

The fat soluble vitamins (A, D, E and K) are absorbed with fats as micelles after conversion to esters. Any disease that reduces bile secretion or blocks the bile duct reduces their absorption [bile is needed for emulsification of fats].

Vitamins B1 (thiamine), B2 (riboflavine), niacin, B6 (pyridoxine) and ascorbic acid (vitamin C) are sodium-dependent as they are absorbed by Na+ cotransporters (mostly in the duodenum). Vitamin B12 and folate absorption do not require sodium.

Thanks,
M
Btw did u use any sources or is this just from memory? Just so that I can do some further reading myself
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macpatgh-Sheldon
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Combination of memory and Ganong's Review of Medical Physiology (McGraw-Hill)
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Tmkz
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(Original post by macpatelgh)
Combination of memory and Ganong's Review of Medical Physiology (McGraw-Hill)
thank you
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