username1003420
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If a patient is on lamatrogine for epilepsy and has depression is it okay to use sertraline to treat the depression?
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Jpw1097
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(Original post by tammie123)
If a patient is on lamatrogine for epilepsy and has depression is it okay to use sertraline to treat the depression?
Yes. Since you are asking this question, you're probably aware that many antidepressants can lower the seizure threshold, increasing the risk of seizures. The selective serotonin reuptake inhibitors (such as sertraline, fluoxetine) are the first-line treatment for depression in patients with epilepsy, and are generally the safest. Monoamine oxidase B inhibitors are also generally safe to use, but aren't used so much anymore since the introduction of newer antidepressants due to their interactions with foods and drugs. Tricyclics (e.g. imipramine) should be avoided or used cautiously in epilepsy as they carry the greatest risk of seizures.
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